#Water in oil emulsion pharmacy drug skin#
#Water in oil emulsion pharmacy drug free#

#Water in oil emulsion pharmacy drug skin#

Ī dysfunctional skin barrier leads to skin dryness and may be due to a genetic predisposition pathological causes such as eczema, psoriasis or xerosis environmental insults from the sun, wind or air conditioning frequent exposure to chemicals such as harsh soaps or detergents medications such as statins, diuretics or retinoids and other causes such as aging. Corneocytes are rapidly and continually replaced to maintain skin hydration, flexibility and structural integrity, and repair any skin damage.

#Water in oil emulsion pharmacy drug free#

The barrier function of the skin resides in the stratum corneum (SC), which is composed of protein enriched corneocyte layers and intercellular membrane lipids, such as ceramides, cholesterol, and free fatty acids. The skin is the outermost defensive barrier, which protects the human body from physical, chemical and microbial insults, and prevents the uncontrolled loss of water. The unique rules imposed by governing regulatory bodies in Australia and around the world, in terms of topical product claims, are also briefly examined. This review examines common topical vehicles used for drug delivery and cosmetic moisturizers, including their formulation, advantages and disadvantages, and effects on the skin. It is crucial that topical vehicles are chosen based upon the size and properties (wet/dry, mucous/non-mucous, healthy/diseased) of the skin to be treated in order to optimize application and contact of the product with the skin, as this can have profound impacts on potency, efficacy, and patient compliance. The most common topical vehicles include ointments, creams, gels, and lotions, among others. Topical vehicles are also used as cosmetic moisturizers (often termed emollient therapy) to ameliorate dry skin, which is a cornerstone of the management of various dermatological conditions, including xerosis, eczema, psoriasis, and aging. Absorption into the systemic circulation is minimized. Instead of applying the active drug directly onto the skin, it is combined with a vehicle to aid in its delivery across the stratum corneum (SC) and into deeper regions of the skin, namely the epidermis and dermis. Many dermatological conditions, such as eczema and psoriasis, are treated with topical therapeutic products.